Binding of ionic ligands to polyelectrolytes

Optimum Conditions of Radioligand Receptor Binding Assay of Ligands of Benzodiazepine Receptors

To obtain drugs which are more selective at benzodiazepine (BZD) receptors, design and synthesis of functionally selective ligands for BZD receptors is the current strategy of our pharmaceutical chemistry department. The affinity of newly synthesized ligands is assessed by radioligand receptor binding assays. Based on our previous studies, 2-phenyl-5-oxo-7-methyl-1,3,4-oxadiazolo[a,2,3]-pyrimid...

Optimum Conditions of Radioligand Receptor Binding Assay of Ligands of Benzodiazepine Receptors

To obtain drugs which are more selective at benzodiazepine (BZD) receptors, design and synthesis of functionally selective ligands for BZD receptors is the current strategy of our pharmaceutical chemistry department. The affinity of newly synthesized ligands is assessed by radioligand receptor binding assays. Based on our previous studies, 2-phenyl-5-oxo-7-methyl-1,3,4-oxadiazolo[a,2,3]-pyrimid...

THE EFFECT OF IONIC STRENGTH ON THE BINDING OF SODIUM N-DODECYL SULPHATE TO ASPERGILLUS NIGER CATALASE

The binding of sodium n-dodecyl sulphate (SDS) to Aspergillus niger catalase in various ionic strengths at pH 6.4 and a temperature of 27? and 37?C has been studied over a range of SDS concentrations using equilibrium dialysis and fluorescence spectroscopy techniques. The binding data were used and interpreted in terms of theoretical models (Scatchard Equation and Wyman Binding Potential). ...

structure activity relationship (sar) investigation on the binding properties of ligands similar to combretastatin to colchicine binding site of tubulin protein as anti-cancer drug

prediction protein binding of drugs using abraham ionic parameters